Tesamorelin- 10mg

Form: Lyophilized powder (10mg)

🔬 Tesamorelin — Overview

Tesamorelin is a synthetic peptide analog of growth hormone–releasing hormone (GHRH) designed to stimulate endogenous growth hormone (GH) secretion from the anterior pituitary. It was engineered to retain biological activity while improving stability and resistance to enzymatic degradation compared with native GHRH. Tesamorelin is studied in endocrine and metabolic research for its effects on GH/IGF-1 axis regulation and body composition.

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📌 Brief Functional Description

• Endogenous GH stimulation: Promotes physiologic, pulsatile growth hormone release rather than direct GH replacement.
• IGF-1 elevation: Downstream GH release increases hepatic IGF-1 production, mediating anabolic and metabolic effects.
• Metabolic relevance: Studied for impacts on fat distribution, lipid metabolism, and metabolic health.
• Research relevance: Used in endocrinology, metabolism, and body-composition research.

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🧪 Chemical & Structural Information

🔢 CAS Number

• 218949-48-5

🧬 Molecular Formula

• C₂₂₁H₃₄₂N₄₆O₆₈

⚖️ Molecular Weight

• ≈5,135.9 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• Tesamorelin is a 44-amino-acid linear peptide.
• It is a modified GHRH analog, with substitutions that:
  • Increase metabolic stability
  • Prolong biological activity
• The peptide lacks disulfide bonds and remains linear, relying on sequence conformation for receptor interaction.

General structural description:

44-amino-acid linear GHRH analog engineered for enhanced stability 

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🧠 Mechanism & Biological Context

• Tesamorelin binds to the GHRH receptor (GHRH-R) on pituitary somatotroph cells.
• Receptor activation triggers cAMP signaling, leading to GH synthesis and release.
• Unlike direct GH administration, tesamorelin preserves normal hypothalamic–pituitary feedback mechanisms, resulting in more physiologic hormone patterns.
• Its effects are mediated indirectly through the GH → IGF-1 axis.

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⚠️ Safety & Regulatory Notes

• Approved pharmaceutical: Tesamorelin has FDA approval for specific medical indications.
• Prescription use: Administration and indications are regulated and context-specific.
• In research contexts, outcomes are dose- and duration-dependent, tied to GH/IGF-1 responsiveness.

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🧪 Quick Reference

Property	Detail
Name	Tesamorelin
CAS #	218949-48-5
Molecular Formula	C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight	~5,135.9 Da
Type	GHRH analog peptide
Length	44 amino acids
Primary Function	Endogenous GH & IGF-1 stimulation

Notice: For Research Use Only. Not for human or veterinary use