TB-500

Form: Lyophilized powder

🔬 TB-500 (Thymosin Beta-4 Fragment) — Overview

TB-500 is a synthetic peptide derived from a biologically active region of thymosin beta-4, a naturally occurring protein involved in cell migration, tissue repair, and actin regulation. TB-500 is used in research settings to study wound healing, angiogenesis, inflammation modulation, and regenerative signaling across multiple tissue types.

📌 Brief Functional Description

• Cell migration & repair: Studied for promoting cell movement and tissue remodeling, key processes in healing and regeneration.
• Actin regulation: Influences actin polymerization, supporting cytoskeletal organization and cellular motility.
• Angiogenesis signaling: Explored for roles in new blood vessel formation in experimental models.
• Research relevance: Used in musculoskeletal, connective tissue, cardiovascular, and regenerative biology research.

🧪 Chemical & Structural Information

🔢 CAS Number

• 885340-08-9

🧬 Molecular Formula

• C₃₈H₆₈N₁₀O₁₄

⚖️ Molecular Weight

• ≈889.0 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• TB-500 is a short synthetic peptide fragment derived from thymosin beta-4.
• Commonly referenced active sequence:
  Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
• The peptide is linear and lacks disulfide bonds.
• Its small size allows rapid tissue diffusion in experimental systems.

General structural description:

Short linear peptide derived from thymosin beta-4 involved in cytoskeletal regulation 

🧠 Mechanism & Biological Context

• TB-500 interacts with G-actin, influencing actin filament dynamics critical for cell migration and wound closure.
• Through actin regulation, it indirectly supports angiogenesis, tissue remodeling, and repair signaling.
• Unlike growth factors or hormones, TB-500 does not act via a specific cell-surface receptor, but through intracellular structural modulation.
• Effects observed in research are context- and dose-dependent.

⚠️ Safety & Regulatory Notes

• Research Use Only: TB-500 is not FDA-approved as a therapeutic drug.
• Widely studied in preclinical and experimental research models.
• Not intended for human therapeutic use outside controlled research environments.

🧪 Quick Reference

Notice: Research use only. Not for human or veterinary use.