SLU-PP-332 5mg

Analytical-grade lyophilized material for use in controlled laboratory environments.

Form: Lyophilized powder (5mg)

🔬 SLU-PP-332 — Overview

SLU-PP-332 is a synthetic small-molecule compound developed as a mitochondrial oxidative phosphorylation (OXPHOS) enhancer and is often described in research literature as an “exercise mimetic.” It was designed to selectively activate estrogen-related receptors (ERRα, ERRβ, and ERRγ), key transcription factors that regulate mitochondrial biogenesis, oxidative metabolism, and energy expenditure. SLU-PP-332 is used exclusively in preclinical research.

📌 Brief Functional Description

• Mitochondrial metabolism: Enhances oxidative phosphorylation capacity and mitochondrial gene expression.
• Exercise-like signaling: Mimics aspects of endurance training by increasing fatty-acid oxidation and aerobic capacity in experimental models.
• Energy expenditure: Studied for increasing basal metabolic rate without direct stimulant effects.
• Research relevance: Used in metabolic disease, obesity, endurance physiology, and mitochondrial biology research.

🧪 Chemical & Structural Information

🔢 CAS Number

• 1616391-73-9

🧬 Molecular Formula

• C₁₈H₁₄F₃NO₃S

⚖️ Molecular Weight

• ≈397.4 g/mol (Da)

🧬 Chemical Structure & Composition

• SLU-PP-332 is a non-peptide, non-hormonal small molecule.
• It contains aromatic rings and a trifluoromethyl group, contributing to metabolic stability and receptor affinity.
• Unlike peptides, it is orally bioactive in animal models and does not require injection in research settings.

General structural description:

Small-molecule ERR agonist with aromatic core and trifluoromethyl substitution 

🧠 Mechanism & Biological Context

• SLU-PP-332 activates estrogen-related receptors (ERRs), which are master regulators of mitochondrial number and function.
• ERR activation increases transcription of genes involved in:
  • Fatty-acid oxidation
  • Electron transport chain activity
  • Mitochondrial respiration
• In animal studies, this leads to improved endurance performance and metabolic efficiency without requiring physical exercise.
• Unlike stimulants or adrenergic agents, its effects are transcriptional and metabolic, not acute or CNS-driven.

⚠️ Safety & Regulatory Notes

• Research Use Only: SLU-PP-332 is not FDA-approved for human use.
• Human safety, pharmacokinetics, and long-term effects are unknown.
• Currently restricted to laboratory and preclinical research environments.

🧪 Quick Reference

Notice: Research use only. Not for human use.