Semax-10mg

Semax-10mg

🔬 Semax — Overview

Semax is a synthetic neuropeptide derived from a modified fragment of adrenocorticotropic hormone (ACTH 4–10), engineered to retain neurotrophic and neuromodulatory activity without hormonal (adrenal) effects. It is primarily studied in research settings for its influence on cognition, neuroprotection, stress response, and synaptic plasticity.

📌 Brief Functional Description

• Cognitive modulation: Studied for effects on learning, memory, attention, and mental clarity.
• Neuroprotection: Explored for protective activity against ischemic injury, oxidative stress, and excitotoxicity in experimental models.
• Neurotrophic signaling: Associated with increased expression of BDNF (brain-derived neurotrophic factor) and related pathways.
• Research relevance: Widely used in neuroscience, cerebrovascular, and cognitive-performance research.

🧪 Chemical & Structural Information

🔢 CAS Number

• 80714-61-0

🧬 Molecular Formula

• C₃₇H₅₁N₉O₁₀S

⚖️ Molecular Weight

• ≈813.9 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• Semax is a linear heptapeptide with the sequence:
  Met-Glu-His-Phe-Pro-Gly-Pro
• It includes a C-terminal proline extension, which improves resistance to enzymatic degradation.
• The peptide does not stimulate adrenal corticosteroid release, differentiating it from native ACTH.

General structural description:

7-amino-acid linear neuropeptide derived from ACTH(4–10) with enhanced stability 

🧠 Mechanism & Biological Context

• Semax modulates dopaminergic, serotonergic, and glutamatergic neurotransmission.
• It influences intracellular signaling pathways involved in synaptic plasticity and neuronal survival, including MAPK/ERK cascades.
• Increased BDNF expression is thought to underlie many of its cognitive and neuroprotective effects.
• Unlike classical stimulants or sedatives, Semax acts as a neuromodulator, not a direct neurotransmitter agonist.

⚠️ Safety & Regulatory Notes

• Research Use Only: Semax is not FDA-approved as a therapeutic drug.
• Studied primarily in controlled laboratory and clinical research environments.
• Reported research data suggest low toxicity and no known dependency profile, though long-term human data are limited.

🧪 Quick Reference