PT-141 10mg

🔬 PT-141 (Bremelanotide) — Overview

PT-141, also known as bremelanotide, is a synthetic cyclic peptide and a melanocortin receptor agonist derived from modifications of α-melanocyte-stimulating hormone (α-MSH). Unlike PDE-5 inhibitors, PT-141 acts centrally in the nervous system rather than through vascular mechanisms. It is studied for its effects on sexual desire, arousal signaling, and central melanocortin pathways.

📌 Brief Functional Description

• Central arousal signaling: Activates melanocortin receptors involved in sexual motivation and arousal.
• Non-vascular mechanism: Does not rely on nitric oxide or blood flow pathways.
• CNS activity: Acts primarily within the hypothalamus and limbic system.
• Research relevance: Studied in neuroendocrinology, sexual health research, and melanocortin receptor pharmacology.

🧪 Chemical & Structural Information

🔢 CAS Number

• 189691-06-3

🧬 Molecular Formula

• C₅₀H₆₈N₁₄O₁₀

⚖️ Molecular Weight

• ≈1,025.2 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• PT-141 is a cyclic heptapeptide structurally related to melanotan analogs.
• Cyclization and amino-acid substitutions:
  • Increase metabolic stability
  • Enhance central receptor affinity
• The cyclic structure is essential for potency and resistance to enzymatic degradation.

General structural description:

Cyclic 7-amino-acid peptide with enhanced CNS stability and melanocortin receptor affinity 

🧠 Mechanism & Biological Context

• PT-141 binds primarily to melanocortin receptors MC3R and MC4R, which regulate sexual behavior, motivation, and autonomic signaling.
• Activation of these receptors modulates dopaminergic and autonomic pathways associated with arousal.
• Because its mechanism is central rather than peripheral, PT-141 is mechanistically distinct from erectile-function drugs that act via vasodilation.

⚠️ Safety & Regulatory Notes

• Prescription status: Bremelanotide is FDA-approved in a specific formulation for certain indications.
• Research context: Peptide forms are also used in controlled research settings to study CNS melanocortin signaling.
• Effects are dose- and context-dependent, with CNS activity being the primary driver of observed responses.

🧪 Quick Reference