Kisspeptin10-10mg

Kisspeptin10-10mg

🔬 Kisspeptin-10 — Overview

Kisspeptin-10 is a synthetic decapeptide derived from the C-terminal active region of the endogenous peptide kisspeptin, encoded by the KISS1 gene. It plays a critical role in reproductive neuroendocrine signaling, acting upstream of gonadotropin release by stimulating gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. Kisspeptin-10 is widely used in research settings to study reproductive hormone regulation and hypothalamic–pituitary–gonadal (HPG) axis function.

📌 Brief Functional Description

• Reproductive hormone regulation: Potently stimulates GnRH release, leading to downstream secretion of LH and FSH.
• Puberty & fertility signaling: Essential for the initiation of puberty and maintenance of normal reproductive function.
• High potency fragment: Kisspeptin-10 retains full biological activity of longer kisspeptin peptides despite its shorter length.
• Research relevance: Used in studies of fertility, hypogonadism, endocrine signaling, and neuroendocrinology.

🧪 Chemical & Structural Information

🔢 CAS Number

• 503468-95-9

🧬 Molecular Formula

• C₆₃H₈₃N₁₇O₁₄

⚖️ Molecular Weight

• ≈1,303 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• Kisspeptin-10 is a 10-amino-acid linear peptide with the sequence:
  Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• The C-terminal amidation is critical for receptor binding and biological activity.
• The peptide adopts a flexible conformation suitable for high-affinity interaction with its receptor.

General structural description:

10-amino-acid linear peptide with C-terminal amidation 

🧠 Mechanism & Biological Context

• Kisspeptin-10 binds to the KISS1 receptor (GPR54) located on GnRH neurons.
• Receptor activation triggers GnRH pulsatile release, which in turn stimulates the pituitary to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
• This signaling cascade is central to puberty onset, ovulation, spermatogenesis, and overall reproductive endocrine balance.
• Unlike direct gonadotropin analogs, kisspeptin-10 acts at the hypothalamic control level, preserving physiologic hormone rhythms.

⚠️ Safety & Regulatory Notes

• Research Use Only: Kisspeptin-10 is not FDA-approved as a therapeutic drug.
• Primarily utilized in laboratory and clinical research investigating reproductive endocrinology.
• Hormonal effects are potent and context-dependent, requiring controlled experimental settings.

🧪 Quick Reference