IGF1-LR3 .1mg(100mcg)

IGF1-LR3 .1mg(100mcg)

🔬 IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) — Overview

IGF-1 LR3 is a synthetic, long-acting analog of human insulin-like growth factor-1 (IGF-1). It was engineered to enhance biological stability, receptor affinity, and circulating half-life compared with native IGF-1. IGF-1 LR3 is primarily used in research settings to study cell growth, protein synthesis, muscle hypertrophy, and tissue regeneration pathways.

📌 Brief Functional Description

• Anabolic signaling: IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), stimulating cellular growth, proliferation, and differentiation.
• Protein synthesis: Promotes amino acid uptake and muscle protein synthesis via PI3K/Akt/mTOR pathways.
• Enhanced stability: Structural modifications significantly reduce binding to IGF-binding proteins (IGFBPs), increasing free, bioactive IGF-1 levels.
• Research relevance: Commonly studied in models of muscle growth, tissue repair, and metabolic signaling.

🧪 Chemical & Structural Information

🔢 CAS Number

• 946870-92-4

🧬 Molecular Formula

• C₉₉₀H₁₅₂₉N₂₆₃O₂₉₉S₇ (modified IGF-1 backbone)

⚖️ Molecular Weight

• ≈9,111 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• IGF-1 LR3 is an 83-amino-acid single-chain polypeptide.
• It differs from native IGF-1 by:
  • Arginine substitution at position 3 (Glu → Arg)
  • 13-amino-acid extension at the N-terminus
• These modifications:
  • Increase half-life
  • Reduce IGFBP binding
  • Enhance receptor interaction
• The peptide contains three disulfide bonds, stabilizing its tertiary structure.

General structural description:

83-amino-acid single-chain peptide with 3 disulfide bridges and N-terminal extension 

(Due to size and complexity, SMILES/InChI strings are not practical; full structural coordinates are available in protein structure databases.)

🧠 Mechanism & Biological Context

• IGF-1 LR3 binds to the IGF-1 receptor, triggering downstream signaling through:
  • PI3K / Akt
  • mTOR
  • MAPK pathways
• These cascades regulate cell survival, growth, glucose uptake, and anabolic activity.
• Unlike HGH, IGF-1 LR3 acts directly at the cellular level and does not require hepatic conversion to exert its effects.

⚠️ Safety & Regulatory Notes

• Research Use Only: IGF-1 LR3 is not FDA-approved for therapeutic use.
• Potent biological activity: Due to strong mitogenic and metabolic effects, it is handled strictly within laboratory and experimental research contexts.
• Appears on anti-doping prohibited lists for athletic competition.

🧪 Quick Reference