HGH 36IU

🔬 HGH 36IU (Human Growth Hormone / Somatropin) — Overview

Human Growth Hormone (HGH), also known as somatropin, is a naturally occurring peptide hormone produced by the anterior pituitary gland. It plays a central role in growth, metabolism, tissue repair, and body composition. HGH acts directly on target tissues and indirectly by stimulating the production of insulin-like growth factor-1 (IGF-1), primarily in the liver.

📌 Brief Functional Description

• Growth & Development: Stimulates linear growth in children and supports tissue growth and regeneration in adults.
• Metabolic Regulation: Promotes lipolysis (fat breakdown), increases protein synthesis, and influences carbohydrate metabolism.
• Endocrine Signaling: Triggers hepatic IGF-1 production, which mediates many anabolic and growth-related effects.
• Physiological Importance: HGH secretion declines with age and is pulsatile, with the largest releases occurring during deep sleep.

🧪 Chemical & Structural Information

🔢 CAS Number

• 12629-01-5 — recombinant human growth hormone (somatropin).

🧬 Molecular Formula

• C₉₉₀H₁₅₂₉N₂₆₃O₂₉₉S₇

⚖️ Molecular Weight

• ≈22,124 g/mol (Da)

🧬 Amino Acid Sequence & Structure

• HGH is a single-chain polypeptide composed of 191 amino acids.
• It contains two internal disulfide bonds that stabilize its three-dimensional conformation.
• The structure is predominantly alpha-helical, which is critical for receptor binding and biological activity.
• Recombinant HGH (somatropin) is structurally identical to endogenous human growth hormone.

(Full SMILES or InChI representations are impractical due to protein size but are available in PDB protein structure databases.)

🧠 Mechanism & Biological Context

• HGH binds to the growth hormone receptor (GHR) on target cells, causing receptor dimerization and activation of JAK-STAT signaling pathways.
• This signaling cascade leads to IGF-1 synthesis, increased amino acid uptake, protein synthesis, and enhanced fat metabolism.
• HGH also has direct metabolic actions, including reduced glucose uptake in adipose tissue and increased lipolysis.

⚠️ Safety & Regulatory Notes

• Prescription biologic: HGH is an FDA-approved medication for specific medical indications (e.g., GH deficiency, certain growth disorders).
• Not a dietary supplement: Non-medical use is regulated and prohibited in many athletic and professional settings.
• Recombinant HGH used in medicine and research is produced via recombinant DNA technology.

🧪 Quick Reference