Enclomiphene 25mg 60ct

Enclomiphene 25mg 60ct

🔬 Enclomiphene — Overview

Enclomiphene is a nonsteroidal selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene citrate. It is the estrogen-antagonist–dominant isomer, distinguishing it from zuclomiphene (the estrogenic isomer). Enclomiphene has been studied primarily for its ability to stimulate endogenous testosterone production by modulating estrogen feedback at the hypothalamic–pituitary level.

📌 Brief Functional Description

• Endogenous testosterone stimulation: Increases LH and FSH secretion, leading to enhanced testicular testosterone production.
• Estrogen feedback modulation: Blocks estrogen receptors in the hypothalamus, reducing negative feedback on GnRH release.
• Fertility preservation context: Studied as an alternative to exogenous testosterone in research models examining hypogonadism with maintained spermatogenesis.
• Research relevance: Used in endocrinology, reproductive health, and male hormone regulation research.

🧪 Chemical & Structural Information

🔢 CAS Number

• 7599-79-3

🧬 Molecular Formula

• C₂₆H₂₈ClNO

⚖️ Molecular Weight

• ≈405.96 g/mol (Da)

🧬 Chemical Structure & Composition

• Enclomiphene is a triphenylethylene derivative, structurally similar to other SERMs.
• It exists as a single geometric isomer (trans), which accounts for its predominantly anti-estrogenic activity.
• Unlike peptide hormones, enclomiphene is a small-molecule oral compound.

General structural description:

Nonsteroidal triphenylethylene SERM with estrogen receptor antagonism 

🧠 Mechanism & Biological Context

• Enclomiphene binds to estrogen receptors (ERα and ERβ) in the hypothalamus.
• This binding blocks estrogen-mediated negative feedback, increasing GnRH pulse frequency.
• Elevated GnRH stimulates the pituitary to release LH and FSH, which:
  • Increase Leydig cell testosterone production
  • Support Sertoli cell–mediated spermatogenesis
• Unlike exogenous androgens, enclomiphene acts upstream, preserving endogenous hormonal signaling loops.

⚠️ Safety & Regulatory Notes

• Investigational / prescription context: Enclomiphene has been evaluated in clinical trials but is not broadly FDA-approved as a standalone product.
• Distinct from clomiphene citrate, which contains both enclomiphene and zuclomiphene isomers.
• Effects are dose- and duration-dependent, reflecting its central endocrine mechanism.

🧪 Quick Reference