DSIP-10mg

DSIP-10mg

🔬 DSIP (Delta-Sleep-Inducing Peptide) — Overview

DSIP (Delta-Sleep-Inducing Peptide) is a naturally occurring neuropeptide originally isolated from the brains of rabbits and investigated for its association with sleep regulation, neuroendocrine function, and stress responses in mammals. It has been studied in multiple species (rabbits, rats, mice, humans) for effects on deep (delta) sleep wave activity and other physiological systems.

⚠️ Important: DSIP is used as a research peptide (not approved for therapeutic use)

🧪 Chemical & Structural Information

🔢 CAS Number

• 62568-57-4 — widely referenced CAS for Delta-Sleep-Inducing Peptide.

🧬 Amino Acid Sequence

• Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  (abbreviated WAGGDASGE; a nonapeptide).

⚖️ Molecular Formula

• C₃₅H₄₈N₁₀O₁₅ — elemental formula of the peptide.

⚖️ Molecular Weight

• ≈848.8 g/mol (Da) — approximate molecular mass of DSIP.

🧬 Chemical Structure

DSIP is a short peptide chain of nine standard amino acids linked by peptide (amide) bonds. In 2-letter or one-letter notation, it’s:

H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH 

…with each side chain contributing to the peptide’s properties (tryptophan for hydrophobicity/aromatic interactions, glycine for flexibility, and charged residues like Asp/Glu).

⚠️ A full SMILES or InChI string encoding of the peptide is long due to all amide bonds and side chains, but can be generated for modeling if needed.

🧠 Research Context & Mechanism

• Named for its association with delta-wave sleep activity in EEG recordings, DSIP was first isolated based on its ability to enhance deep sleep patterns in rabbits.
• DSIP has also been studied for potential effects on stress, circadian rhythms, hormone release (e.g., LH/ACTH), and thermoregulation, though mechanisms and reproducibility are variable and often poorly defined.
• Despite its name, the precise physiological role of DSIP in humans remains incomplete and controversial — no definitive receptor or gene has been identified.

⚠️ Safety & Regulatory Notes

• Research Use Only: DSIP is generally supplied for laboratory and investigational research; it is not approved as a therapeutic agent or dietary supplement.
• Peptides like DSIP are typically studied via in vitro or in vivo experimental protocols and not standardized clinical drugs.

🧪 Quick Reference