AOD-9604 -5mg

🔬 AOD-9604 — Overview

AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (HGH) (specifically residues 176–191) that was developed to mimic the lipolytic (fat-breaking) effects of HGH without the broader growth-promoting effects like increasing IGF-1. It has been studied in research settings for fat metabolism, lipolysis, and adipocyte signaling, although clinical efficacy in humans hasn’t been consistently demonstrated.

📌 Brief Functional Description

• Modified fragment of human growth hormone designed to enhance fat breakdown and inhibit fat formation.
• Investigated primarily in preclinical and early human trials for lipolytic activity with minimal effects on glucose/IGF-1.
• Often referred to as the “fat-burning peptide” in research literature.

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🧪 Chemical & Structural Information

🔢 CAS Number

• 221231-10-3 — widely accepted CAS for AOD-9604.

🧬 Amino Acid Sequence

• AOD-9604 is a 16-amino acid peptide (e.g., Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe) with a disulfide bridge linking the two cysteines (commonly a cyclic structure).

⚖️ Molecular Formula

• C₇₈H₁₂₃N₂₃O₂₃S₂ — the elemental composition of the peptide fragment.

🧪 Molecular Weight

• ~1,815.1 g/mol (Da) — approximate molecular weight of the AOD-9604 peptide.

🧬 Chemical Structure

• AOD-9604 is a peptide, meaning its structure consists of amino acids linked by amide (peptide) bonds in the sequence shown above.
• The peptide also includes a 7→14 disulfide (cyclic) bond between the two cysteine residues, which stabilizes the folded peptide chain.
• A simplified structural depiction can be represented as:

  Tyr–Leu–Arg–Ile–Val–Gln–Cys    |——————disulfide bridge——————|                          Cys–Gly–Phe 

  (Connected peptide chain with standard side chains for each residue.)

  Note: The full 2D SMILES or InChI string for the intact peptide is extensive (163+ atoms) and reflects the full backbone plus the sulfur–sulfur bond and all side chains; this is consistent with the 16-amino-acid length.

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🧠 Mechanism & Research Context

• AOD-9604 was designed to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat creation) in adipose tissue without traditional growth hormone receptor activation.
• Animal studies showed enhanced fat oxidation and reduced fat accumulation, possibly through beta-adrenergic receptor–related pathways.
• Human clinical data to date are limited and inconsistent, and its development was not completed as a therapeutic due to insufficient efficacy.

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⚠️ Additional Notes

• AOD-9604 is research-use-only in most contexts (not approved as a drug or supplement).
• It does not reliably raise IGF-1 or full HGH receptor activity, differentiating it from full growth hormone.